IFN alpha-IFNAR-IN-1 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IFN α-IFNAR-IN-1 saltchide 是 IFN-α 和 IFNAR 之间相互作用的抑制剂。 IFN α-IFNAR-IN-1 saltchide 抑制 BM-pDCs 诱导的 MVA IFN-α 反应，IC50 为 2-8 μM。

IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 μM.(In Vitro):IFN alpha-IFNAR-IN-1 hydrochloride inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 hydrochloride specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 hydrochloride exerts immunosuppressive activity by the direct interaction with IFN-α.

IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs.

——

——

Others

Other Targets

antimalarial

——

——

2070014-98-9

315.86

C18H18ClNS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (316.60 mM)

Cl.CNCc1ccccc1Sc1cccc2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years